Investigating Decision-making and Reward In Schizophrenia 



2014 (& in press)


Doll, B.B., Waltz, J.A., Cockburn, J., Brown, J.K., Frank, M.J., Gold, J.M. (In Press). Reduced susceptibility to confirmation bias in schizophrenia. Cognitive, Affective, and Behavioral Neuroscience. Epub 2014 Jan 31. PMID: 24481852. PDF


Strauss, G.P., Waltz, J.A., Gold, J.M. (In Press). A review of reward processing and motivational impairment in schizophrenia. Schizophrenia Bulletin, 40, S107-16. Epub 2013 Dec 27. PMID: 24375459. PMCID: PMC3934394. PDF


Rose, E.J., Salmeron, B.J., Ross, T.J., Waltz, J., Schweitzer, J.B., McClure, S.M., Stein, E.A. (In Press). Temporal Difference Error Prediction Signal Dysregulation in Cocaine Dependence. Neuropsychopharmacology. Epub 2014 Jan 29. PMID: 24569319. PDF




Waltz, J.A., Kasanova, Z., Ross, T.J., Salmeron, B.J., McMahon, R.P., Gold, J.M., Stein, E.A. (2013). The roles of reward, default, and executive control networks in set-shifting impairments in schizophrenia. PLoS-ONE, 8, e57257. PDF


Brown, J.K., Waltz, J.A., Strauss, G.P., McMahon, R.P., Frank, M.J., Gold, J.M. (2013). Hypothetical decision making in schizophrenia: The role of expected value computation and "irrational" biases. Psychiatry Research, 202, 142-149. PDF


Gold, J.M., Strauss, G.P., Waltz, J.A., Robinson, B.M., Brown, J.K., Frank, M.J. (2013). Negative Symptoms of Schizophrenia Are Associated with Abnormal Effort-Cost Computations. Biological Psychiatry, 74, 130-136. PDF




Gold, J.M. Waltz, J.A., Matveeva, T.M., Kasanova, Z., Strauss, G.P., Herbener, E.S., Collins, A.G.E., Frank, M.J. (2012). Negative symptoms in schizophrenia result from a failure to represent the expected value of rewards: Behavioral and computational modeling evidence. Archives of General Psychiatry, 69, 129-138. PDF


Strauss, G.P., Lee, B.G., Waltz, J.A., Robinson, B.M., Brown, J.K., Gold, J.M. (2012). Cognition-emotion interactions are modulated by working memory capacity in individuals with schizophrenia. Schizophrenia Research, 141, 257-261. PDF


Simpson, E.H., Waltz, J.A., Kellendonk, C., Balsam, P.D. (2012). Schizophrenia in Translation: Dissecting Motivation in Schizophrenia and Rodents. Schizophrenia Bulletin, 38, 1111-1117. PDF




Waltz, J.A., Frank, M.J., Wiecki, T.V., Gold, J.M. (2011). Altered probabilistic learning and response biases in schizophrenia: Behavioral evidence and neurocomputational modeling. Neuropsychology, 25, 86-97. PDF


Strauss, G.P., Robinson, B.M., Waltz, J.A., Frank, M.J., Kasanova, Z., Herbener, E.S., Gold, J.M. (2011). Patients with schizophrenia demonstrate inconsistent preference judgments for affective and non-affective stimuli. Schizophrenia Bulletin, 37, 1295-1304. PDF


Kasanova, Z., Waltz, J.A., Strauss, G.P., Frank, M.J., Gold, J.M. (2011). Optimizing vs. Matching: Response Strategy in a Probabilistic Learning Task is associated with Negative Symptoms of Schizophrenia. Schizophrenia Research, 127, 215-222. PDF


Strauss, G.P.*, Frank, M.F.*, Waltz, J.A., Kasanova, Z., Herbener, E.S., Gold, J.M. (2011). Deficits in Positive Reinforcement Learning and Uncertainty-Driven Exploration are Associated with Distinct Aspects of Negative Symptoms in Schizophrenia. Biological Psychiatry, 69, 424-431. (*authors contributed equally to this work). PDF


Boggs, D.L., Kelly, D.L., McMahon, R.P., Gold, J.M., Gorelick, D.A., Linthicum, J., Conley, R.R., Liu, F., Waltz, J., Huestis, M.A., Buchanan, R.W. (2011). Rimonabant for neurocognition in schizophrenia: a 16-week double blind randomized placebo controlled trial. Schizophrenia Research, 134, 207-210. PDF




Waltz, J.A., Schweitzer, J.B., Ross, T.J., Kurup, P.K., Salmeron, B.J., Rose, E.J., Gold, J.M., Stein, E.A. (2010). Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophrenia. Neuropsychopharmacology, 35, 2427-39. PDF




Gold, J.M., Hahn, B., Strauss, G.P., Waltz, J.A. (2009). Turning it upside down: areas of preserved cognitive function in schizophrenia. Neuropsychology Review, 19, 294-311. PDF


Haenschel, C., Bittner, R., Waltz, J.A., Haertling, F., Wibral, M., Singer, W., Linden, D.E.J., and Rodriguez, E. (2009). Cortical oscillatory activity is critical for working memory as revealed by deficits in early onset schizophrenia. Journal of Neuroscience, 29, 9481-89. PDF


Pipa, G., Städtler, E.S., Rodriguez, E.F., Waltz, J.A., Muckli, L.F., Singer, W., Goebel, R., Munk, M.H. (2009). Performance- and stimulus-dependent oscillations in monkey prefrontal cortex during short-term memory. Frontiers in Integrative Neuroscience, 3, 25. PDF




Gold, J.M., Waltz, J.A., Prentice, K.J., Morris, S.E., Heerey, E.A. (2008). Reward Processing in Schizophrenia: A Deficit in the Representation of Value. Schizophrenia Bulletin 34, 835-847. PDF




Lu, H., Zuo, Y., Gu, H., Waltz, J.A., Zhan, W., Scholl, C.A., Rea, W., Yang, Y., and Stein, E.A. (2007). Synchronized Delta Oscillations Correlate with the Resting-state fMRI Signal. Proc. Natl. Academy Sciences, 104, 18265-18269. PDF


Waltz, J.A., Frank, M.J., Robinson, B.M., and Gold, J.M. (2007). Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striato-cortical dysfunction. Biological Psychiatry 62, 756-764. PDF


Waltz, J.A., and Gold, J.M. (2007). Probabilistic reversal learning impairments in schizophrenia: further evidence of orbitofrontal dysfunction. Schizophrenia Research 93, 296-303. PDF




Waltz, J.A., Knowlton, B.J., Holyoak, K.J., Boone, K.B., Back, C., McPherson, S., Masterman, D., Chow, T., Cummings, J.L., and Miller, B.L. (2004). Relational integration and executive function in Alzheimer’s disease. Neuropsychology 18, 296-305. PDF


Linden, D.E.J., Bittner, R.A., Muckli, L., Waltz, J.A., Kriegeskorte, N., Goebel, R., Singer, W., and Munk, M.H.J. (2003). Cortical capacity constraints for visual working memory: Dissociation of fMRI load effects in a fronto-parietal network. NeuroImage, 20, 1518-1530. PDF


Waltz, J.A., Lau, A., Grewal, S., and Holyoak, K.J. (2000). The role of working memory in analogical reasoning. Memory & Cognition, 28, 1205-1212. PDF


Waltz, J.A., Knowlton, B.J., Holyoak, K.J., Boone, K.B., Mishkin, F.S., de Menezes Santos, M., Thomas, C.R., and Miller, B.L. (1999). A system for relational reasoning in human prefrontal cortex. Psychological Science, 10, 119-125. PDF






Updated April 2014